CYGD: the Comprehensive Yeast Genome Database.

U. Güldener (1, 2) , M. Münsterkötter (2) , G. Kastenmüller (2) , N. Strack (2) , J. van Helden (3) , C. Lemer (3, 4) , J. Richelles (3) , S. J. Wodak (3) , J. García-Martínez (3) , J. E. Pérez-Ortín (3) , H. Michael (3, 5, 6) , A. Kaps (3) , E. Talla (3, 7) , B. Dujon (7) , Bernard André (3, 8, 9) , J. L. Souciet (10, 11) , J. de Montigny (10, 11) , Elisabeth Bon (12) , C. Gaillardin (13, 12, 14) , H. W. Mewes (1, 2, 3)

1 TUM - Technische Universität Munchen - Technical University Munich - Université Technique de Munich
2 MIPS - Institute for Bioinformatics
3 BRGM - Bureau de Recherches Géologiques et Minières (BRGM)
4 LCogn - Neuroimagerie cognitive
5 IBCP - Institut de biologie et chimie des protéines [Lyon]
6 LEGS - Laboratoire Evolution, Génomes et Spéciation
7 Génétique Moléculaire des Levures
8 CEA-LETI - Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information
9 STEF - Sciences Techniques Éducation Formation
10 DEEGM - Dynamique, évolution et expression de génomes de microorganismes
11 GMGM - Génétique moléculaire, génomique, microbiologie
12 Laboratoire de génétique moléculaire et cellulaire
13 Collection de Levures d'Intérêt Biotechnologique et Laboratoire de Génétique Moléculaire et Cellulaire
14 MGM - Microbiologie et Génétique Moléculaire

The Comprehensive Yeast Genome Database (CYGD) compiles a comprehensive data resource for information on the cellular functions of the yeast Saccharomyces cerevisiae and related species, chosen as the best understood model organism for eukaryotes. The database serves as a common resource generated by a European consortium, going beyond the provision of sequence information and functional annotations on individual genes and proteins. In addition, it provides information on the physical and functional interactions among proteins as well as other genetic elements. These cellular networks include metabolic and regulatory pathways, signal transduction and transport processes as well as co-regulated gene clusters. As more yeast genomes are published, their annotation becomes greatly facilitated using S.cerevisiae as a reference. CYGD provides a way of exploring related genomes with the aid of the S.cerevisiae genome as a backbone and SIMAP, the Similarity Matrix of Proteins. The comprehensive resource is available under http://mips.gsf.de/genre/proj/yeast/.

Mots clés: COMPREHENSIVE YEAST GENOME DATABASE; CYGD; EUROPEAN CONSORTIUM; SEQUENCE INFORMATION; YEAST GENOME; SEQUENCED EUKARYOTIC GENOME

Mots clés: SACCHAROMYCES CEREVISIAE GENOME; PROTEIN INTERACTION

Domaines: Bio-Informatique, Biologie Systémique [q-bio.QM]; Bio-informatique [q-bio.QM]

U. Güldener, M. Münsterkötter, G. Kastenmüller, N. Strack, J. van Helden, et al.. CYGD: the Comprehensive Yeast Genome Database.. Nucleic Acids Research, 2005, 33 (Database issue), pp.D364-8. ⟨10.1093/nar/gki053⟩. ⟨inria-00339841⟩