D. Aliza, I. S. Ismail, M. K. Kuah, A. C. Shu-chien, and T. S. Muhammad, Identification of Wap65, a human homologue of hemopexin as a copper-inducible gene in swordtail fish, Xiphophorus helleri, Fish Physiology and Biochemistry, vol.163, issue.2, pp.129-138, 2008.
DOI : 10.1007/s10695-007-9153-6

A. Amores, A. Force, Y. L. Yan, L. Joly, C. Amemiya et al., Zebrafish hox Clusters and Vertebrate Genome Evolution, Science, vol.282, issue.5394, pp.1711-1714, 1998.
DOI : 10.1126/science.282.5394.1711

M. Canli and G. Atli, The relationships between heavy metal (Cd, Cr, Cu, Fe, Pb, Zn) levels and the size of six Mediterranean fish species, Environmental Pollution, vol.121, issue.1, pp.129-136, 2003.
DOI : 10.1016/S0269-7491(02)00194-X

J. M. Choubert, M. Pomiès, S. Martin, and M. Coquery, Influent concentrations and removal performances of metals through municipal wastewater treatment processes, Water Science & Technology, vol.63, issue.9, pp.1967-1973, 2011.
DOI : 10.2166/wst.2011.126

C. Y. Choi, K. W. An, Y. K. Choi, P. G. Jo, and B. H. Min, Expression of Wap65 mRNA and physiological changes with increasing temperature in black porgy, Acanthopagrus schlegeli, J. Exp. Zool, vol.309, pp.206-214, 2008.

M. S. Clark and G. Burns, Characterisation of the warm acclimated protein gene (wap65) in the Antarctic plunderfish (Harpagifer antarcticus) DNA Seq, pp.50-55, 2008.

R. Dallinger, M. Egg, G. Kock, and R. Hofer, The role of metallothionein in cadmium accumulation of Arctic char (Salvelinus alpinus) from high alpine lakes, Aquatic Toxicology, vol.38, issue.1-3, pp.47-66, 1997.
DOI : 10.1016/S0166-445X(96)00840-5

H. Dooley, E. B. Buckingham, M. F. Criscitiello, and M. Flajnik, Emergence of the acute-phase protein hemopexin in jawed vertebrates, Molecular Immunology, vol.48, issue.1-3, pp.147-152, 2010.
DOI : 10.1016/j.molimm.2010.08.015

G. Dugo, L. Pera, L. Bruzzese, A. Pellicanò, T. M. et al., Concentration of Cd (II), Cu (II), Pb (II), Se (IV) and Zn (II) in cultured sea bass (Dicentrarchus labrax) tissues from Tyrrhenian Sea and Sicilian Sea by derivative stripping potentiometry, Cu (II), Pb (II), pp.146-152, 2006.
DOI : 10.1016/j.foodcont.2004.09.014

J. L. Franco, T. Posser, J. J. Mattos, A. Sanchez-chardi, R. Trevisan et al., Biochemical alterations in juvenile carp (Cyprinus carpio) exposed to zinc: Glutathione reductase as a target, Marine Environmental Research, vol.66, issue.1, pp.88-89, 2008.
DOI : 10.1016/j.marenvres.2008.02.031

R. Gabbianelli, G. Lupidi, M. Villarini, and G. Falcioni, DNA Damage Induced by Copper on Erythrocytes of Gilthead Sea Bream Sparus aurata and Mollusk Scapharca inaequivalvis, Archives of Environmental Contamination and Toxicology, vol.45, issue.3, pp.350-356, 2003.
DOI : 10.1007/s00244-003-2171-1

A. Y. Gracey, J. V. Troll, and G. N. Somero, Hypoxiainduced gene expression profiling in the euryoxic fish Gillichthys mirabilis, pp.1993-1998, 2001.

M. Hirayama, M. Nakaniwa, D. Ikeda, N. Hirazawa, T. Otaka et al., Primary structures and gene organizations of two types of Wap65 from the pufferfish Takifugu rubripes, Fish Physiology and Biochemistry, vol.29, issue.3, pp.211-224, 2003.
DOI : 10.1023/B:FISH.0000045723.52428.5e

M. Hirayama, A. Kobiyama, S. Kinoshita, and S. Watabe, The occurrence of two types of hemopexin-like protein in medaka and differences in their affinity to heme, Journal of Experimental Biology, vol.207, issue.8, pp.1387-1398, 2004.
DOI : 10.1242/jeb.00897

C. Hogstrand, S. Balesaria, and C. N. Glover, Application of genomics and proteomics for study of the integrated response to zinc exposure in a non-model fish species, the rainbow trout, Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, vol.133, issue.4, pp.523-535, 2002.
DOI : 10.1016/S1096-4959(02)00125-2

L. Hollis, J. C. Mc-geer, D. C. Mc-donald, and G. M. Wood, Cadmium accumulation, gill Cd binding, acclimation, and physiological effects during long term sublethal Cd exposure in rainbow trout, Aquatic Toxicology, vol.46, issue.2, pp.101-119, 1999.
DOI : 10.1016/S0166-445X(98)00118-0

G. K. Iwama, P. T. Thomas, R. B. Forsyth, and M. M. Vijayan, Heat shock protein expression in fish, Reviews in Fish Biology and Fisheries, vol.8, issue.1, pp.35-56, 1999.
DOI : 10.1023/A:1008812500650

J. H. Kagi and A. Schaffer, Biochemistry of metallothionein, Biochemistry, vol.27, issue.23, pp.8509-8515, 1988.
DOI : 10.1021/bi00423a001

K. Kikuchi, S. Watabe, Y. Suzuki, K. Aida, and H. Nakajima, The 65-kDa cytosolic protein associated with warm temperature acclimation in goldfish, Carassius auratus, Journal of Comparative Physiology B, vol.163, issue.5, pp.349-354, 1993.
DOI : 10.1007/BF00265637

K. Kikuchi, M. Yamashita, S. Watabe, and K. Aida, The Warm Temperature Acclimation-related 65-kDa Protein, Wap65, in Goldfish and Its Gene Expression, Journal of Biological Chemistry, vol.270, issue.29, pp.17087-17092, 1995.
DOI : 10.1074/jbc.270.29.17087

K. Kikuchi, S. Watabe, K. Aida, S. Kinoshita, S. Itoi et al., The Wap65 gene expression of goldfish (Carassius auratus) in association with warm water temperature as well as bacterial lipopolysaccharide (LPS) cDNA cloning characterization of the warm-temperatureacclimationassociated protein Wap65 from carp, Cyprinus carpio, Fish Physiology and Biochemistry, vol.17, issue.1/6, pp.423-432, 1997.
DOI : 10.1023/A:1007768531655

C. D. Klaassen, J. Liu, and S. Choudhuri, METALLOTHIONEIN: An Intracellular Protein to Protect Against Cadmium Toxicity, Annual Review of Pharmacology and Toxicology, vol.39, issue.1, pp.267-294, 1999.
DOI : 10.1146/annurev.pharmtox.39.1.267

K. K. Lie, A. Lanzen, H. Breilid, and P. A. Olsvik, GENE EXPRESSION PROFILING IN ATLANTIC COD (GADUS MORHUA L.) FROM TWO CONTAMINATED SITES USING A CUSTOM-MADE cDNA MICROARRAY, Environmental Toxicology and Chemistry, vol.28, issue.8, pp.1711-1721, 2009.
DOI : 10.1897/08-517.S2

K. K. Lie, S. Meier, and P. A. Olsvik, Effects of environmental relevant doses of pollutants from offshore oil production on Atlantic cod (Gadus morhua), Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, vol.150, issue.2
DOI : 10.1016/j.cbpc.2009.04.004

Y. Louis, C. Garnier, V. Lenoble, S. Mounier, N. Cukrov et al., Kinetic and equilibrium studies of copper-dissolved organic matter complexation in water column of the stratified Krka River estuary (Croatia), Marine Chemistry, vol.114, issue.3-4, pp.110-119, 2009.
DOI : 10.1016/j.marchem.2009.04.006
URL : https://hal.archives-ouvertes.fr/hal-00739892

N. H. Morley, J. D. Burton, S. P. Tankere, and J. M. Martin, Distribution and behaviour of some dissolved trace metals in the western Mediterranean Sea, Deep Sea Research Part II: Topical Studies in Oceanography, vol.44, issue.3-4, pp.675-691, 1997.
DOI : 10.1016/S0967-0645(96)00098-7

M. Nakaniwa, M. Hirayama, A. Shimizu, T. Sasaki, S. Asakawa et al., Genomic sequences encoding two types of medaka hemopexin-like protein Wap65, and their gene expression profiles in embryos, Journal of Experimental Biology, vol.208, issue.10, pp.1915-1925, 2005.
DOI : 10.1242/jeb.01570

P. A. Olsvik, M. Brattås, K. K. Lie, and A. Goksøyr, Transcriptional responses in juvenile Atlantic cod (Gadus morhua) after exposure to mercury-contaminated sediments obtained near the wreck of the German WW2 submarine U-864, and from Bergen Harbor, Western Norway, Chemosphere, vol.83, issue.4, pp.552-563, 2011.
DOI : 10.1016/j.chemosphere.2010.12.019

M. Paoli, B. F. Anderson, H. M. Baker, W. T. Morgan, . Smith et al., Crystal structure of hemopexin reveals a novel high-affinity heme site formed between two beta-propeller domains, Nat. Struct. Biol, vol.6, pp.926-931, 1999.

S. Pierre, Contribution à la pisciculture marine

S. Pierre, S. Coupé, N. Prévot-d-'alvise, S. Gaillard, S. Richard et al., Cloning of Wap65 in sea bass (Dicentrarchus labrax) and sea bream (Sparus aurata) and expression in sea bass tissues, Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, vol.155, issue.4, pp.396-402, 2010.
DOI : 10.1016/j.cbpb.2010.01.002

N. Prévot-d-'alvise, S. Pierre, S. Gaillard, E. Gouze, J. N. Gouze et al., cDNA sequencing and expression analysis of Dicentrarchus labrax heme oxygenase-1, Cell. Mol. Biol, vol.54, pp.1046-1054, 2008.

R. Development and C. Team, R: A language and environment for statistical computing. R Foundation for Statistical Computing, 2008.

S. Rozen and H. Skaletsky, Primer3 on the WWW for General Users and for Biologist Programmers, Methods Mol. Biol, vol.132, pp.365-386, 2000.
DOI : 10.1385/1-59259-192-2:365

E. Sarropoulou, J. M. Fernandes, K. Mitter, A. Magoulas, V. Mulero et al., Evolution of a multifunctional gene: The warm temperature acclimation protein Wap65 in the European seabass Dicentrarchus labrax, Molecular Phylogenetics and Evolution, vol.55, issue.2, pp.640-649, 2010.
DOI : 10.1016/j.ympev.2009.10.001

Z. Sha, P. Yu, T. Takano, H. Liu, J. Terhune et al., The warm temperature acclimation protein Wap65 as an immune response gene: Its duplicates are differentially regulated by temperature and bacterial infections, Molecular Immunology, vol.45, issue.5, pp.1458-1469, 2008.
DOI : 10.1016/j.molimm.2007.08.012

Y. H. Shi, J. Chen, C. H. Li, and M. Y. Li, Molecular cloning of liver Wap65 cDNA in ayu (Plecoglossus altivelis) and mRNA expression changes following Listonella anguillarum infection, Molecular Biology Reports, vol.37, issue.13, pp.1523-1529, 2009.
DOI : 10.1007/s11033-009-9551-1

C. J. Schmitt, J. J. Whyte, A. P. Roberts, M. L. Annis, T. W. May et al., Biomarkers of metals exposure in fish from lead-zinc mining areas of Southeastern Missouri, USA, Transcript and protein environmental biomarkers in fish. A review, pp.31-47, 2002.
DOI : 10.1016/j.ecoenv.2006.12.011

R. Van-der-oost, J. Beyer, and N. P. Vermeulen, Fish bioaccumulation and biomarkers in environmental risk assessment: a review, Environmental Toxicology and Pharmacology, vol.13, issue.2, pp.57-149, 2003.
DOI : 10.1016/S1382-6689(02)00126-6

S. Watabe, K. Kikuchi, A. K. Williams, T. D. Diab, A. M. George et al., Cold and warmtemperature acclimation induces specific cytosolic protein in goldfish and carp. Nippon Suisan Gakkaishi Development of the GENIPOL European flounder (Platichthys flesus) microarray and determination of temporal transcriptional responses to cadmium at low dose, Transcriptomic responses of European flounder (Platichthys flesus) to model toxicants, pp.151-156, 1993.