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Towards eco‐friendly biocides: preparation, antibiofilm activity of hemibastadin analogues

Abstract : Significance and Impact of the Study: This study reports relevant information about antibiofilm activity of original derivatives of hemibastadin alkaloids. The most active compound was shown to act as a specific anti-biofilm inhibitor without affecting viability of the targeted bacteria no more than those of the global bacterial community of a seawater sample. Taken together, these findings indicate the potentiality of such compounds to be used as original nonbiocidal molecules for designing eco-friendly antifouling solutions. Abstract The antibiofilm activity of three hemibastadins analogues was evaluated against different marine bacterial strains through mono-species biofilms and through a multi-species model of biofilm. Results showed that compound 3 exhibited interesting antibiofilm efficiencies effective concentrations (EC 50) in the range of 30-100 lmol l À1 without acute toxicity against bacteria. Toxicity against nontargeted organisms was also considered showing that the compound did not affect the global bacterial community at a concentration of 75-100 lmol l À1. These results provided baseline data concerning the toxicity of antibiofilm biocides against marine organisms.
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Submitted on : Friday, March 22, 2019 - 11:21:06 AM
Last modification on : Saturday, March 19, 2022 - 11:44:02 AM

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Jean-Louis Jamet, A. Kacou, A. Ouvrard, Y. Blache, Dominique Jamet. Towards eco‐friendly biocides: preparation, antibiofilm activity of hemibastadin analogues. Letters in Applied Microbiology, Wiley, 2019, Biofilm in healthcare settings and their control, 68 (4), pp.360-368. ⟨10.1111/lam.13150⟩. ⟨hal-02076588⟩



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