Towards eco‐friendly biocides: preparation, antibiofilm activity of hemibastadin analogues - Archive ouverte HAL Access content directly
Journal Articles Letters in Applied Microbiology Year : 2019

Towards eco‐friendly biocides: preparation, antibiofilm activity of hemibastadin analogues

(1) , (2) , (2, 1) , (2) , (1)
1
2

Abstract

Significance and Impact of the Study: This study reports relevant information about antibiofilm activity of original derivatives of hemibastadin alkaloids. The most active compound was shown to act as a specific anti-biofilm inhibitor without affecting viability of the targeted bacteria no more than those of the global bacterial community of a seawater sample. Taken together, these findings indicate the potentiality of such compounds to be used as original nonbiocidal molecules for designing eco-friendly antifouling solutions. Abstract The antibiofilm activity of three hemibastadins analogues was evaluated against different marine bacterial strains through mono-species biofilms and through a multi-species model of biofilm. Results showed that compound 3 exhibited interesting antibiofilm efficiencies effective concentrations (EC 50) in the range of 30-100 lmol l À1 without acute toxicity against bacteria. Toxicity against nontargeted organisms was also considered showing that the compound did not affect the global bacterial community at a concentration of 75-100 lmol l À1. These results provided baseline data concerning the toxicity of antibiofilm biocides against marine organisms.

Dates and versions

hal-02076588 , version 1 (22-03-2019)

Identifiers

Cite

Jean-Louis Jamet, A. Kacou, A. Ouvrard, Y. Blache, Dominique Jamet. Towards eco‐friendly biocides: preparation, antibiofilm activity of hemibastadin analogues. Letters in Applied Microbiology, 2019, Biofilm in healthcare settings and their control, 68 (4), pp.360-368. ⟨10.1111/lam.13150⟩. ⟨hal-02076588⟩
129 View
1 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More