Towards eco‐friendly biocides: preparation, antibiofilm activity of hemibastadin analogues

Jean-Louis Jamet 1 A. Kacou 2 A. Ouvrard 2, 1 Y. Blache 2 Dominique Jamet 1
1 MIO - Institut méditerranéen d'océanologie
2 MAPIEM - Laboratoire Matériaux Polymères Interfaces Environnement Marin - EA 4323
Abstract : Significance and Impact of the Study: This study reports relevant information about antibiofilm activity of original derivatives of hemibastadin alkaloids. The most active compound was shown to act as a specific anti-biofilm inhibitor without affecting viability of the targeted bacteria no more than those of the global bacterial community of a seawater sample. Taken together, these findings indicate the potentiality of such compounds to be used as original nonbiocidal molecules for designing eco-friendly antifouling solutions. Abstract The antibiofilm activity of three hemibastadins analogues was evaluated against different marine bacterial strains through mono-species biofilms and through a multi-species model of biofilm. Results showed that compound 3 exhibited interesting antibiofilm efficiencies effective concentrations (EC 50) in the range of 30-100 lmol l À1 without acute toxicity against bacteria. Toxicity against nontargeted organisms was also considered showing that the compound did not affect the global bacterial community at a concentration of 75-100 lmol l À1. These results provided baseline data concerning the toxicity of antibiofilm biocides against marine organisms.
Keywords : biocides biocontrol biofilms ecotoxicity
Document type :
Journal articles
Complete list of metadatas
https://hal-univ-tln.archives-ouvertes.fr/hal-02076588
Contributor : Jean-Louis Jamet <>
Submitted on : Friday, March 22, 2019 - 11:21:06 AM
Last modification on : Thursday, October 10, 2019 - 12:40:45 AM

Identifiers

Collections

UNIV-TLN | MAPIEM | UNIV-AMU | MIO | OSU-INSTITUT-PYTHEAS

Citation

Jean-Louis Jamet, A. Kacou, A. Ouvrard, Y. Blache, Dominique Jamet. Towards eco‐friendly biocides: preparation, antibiofilm activity of hemibastadin analogues. Letters in Applied Microbiology, Wiley, 2019, Biofilm in healthcare settings and their control, 68 (4), pp.360-368. ⟨10.1111/lam.13150⟩. ⟨hal-02076588⟩

Export

BibTeX TEI DC DCterms EndNote

Share

Metrics

Record views

72

Contact

support.ccsd.cnrs.fr
hal.support@ccsd.cnrs.fr
Logo CCSD