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Muscle function and architecture in children with juvenile idiopathic arthritis

Abstract : Aim: To assess muscle function and functional abilities in children with juvenile idiopathic arthritis (JIA). Methods: Fourteen children with JIA and 14 healthy controls matched for age and sex were included. Muscle characteristics, both structural (thickness, cross-sectional area (CSA) and fascicle angle) and qualitative (intermuscular adipose tissue : IMAT) were assessed on thigh muscles using ultrasound and peripheral quantitative computed tomography (pQCT). Muscle function and functional abilities were determined from the assessment of maximal voluntary isometric contraction force (MVIC) of the knee extensors and vertical jump performance. Results: No significant difference in MVIC force was observed between both groups. However, squat jump height was significantly reduced in children with JIA (18.3 ± 5.4 vs 24.3 ± 7.9 cm, p<0.05). Furthermore, no difference in structural parameters was observed. Nevertheless, IMAT/CSA (0.22 ± 0.02 vs 0.25 ± 0.03 mm 2 ; p=0.01) was significantly lower in children with JIA compared to healthy peers. Conclusion: Muscle dimensions, architecture and function were comparable between children with JIA and healthy children. Only IMAT area was found to be lower in JIA. These outcomes could be associated with a lower physical activity level in children with JIA compared to healthy children.
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Submitted on : Thursday, November 26, 2020 - 10:02:56 AM
Last modification on : Thursday, December 10, 2020 - 1:44:46 PM

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Pierre Bourdier, Anthony Birat, Emmanuelle Rochette, Éric Doré, Daniel Courteix, et al.. Muscle function and architecture in children with juvenile idiopathic arthritis. Acta Paediatrica, Wiley, 2020, ⟨10.1111/apa.15335⟩. ⟨hal-03024973⟩

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